KKGT  Stichting Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

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WELCOME TO THE ASSOCIATION FOR QUALITY ASSESSMENT IN THERAPEUTIC DRUG MONITORING AND CLINICAL TOXICOLOGY

Welcome to the KKGT, which stand for  “Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology”.

The objective of the association is to stimulate the quality of  Therapeutic Drug Monitoring,  Clinical Toxicology and the analysis of other corporal-strange substances in laboratories. This includes determination of serumlevels, pharmacokinetic calculations and simulations, interpretation, together  resulting in a treatment advice to the physician.  

The Association has Articles, an Executive and an office. Participants to KKGT-EQAS will subscribe yearly to the programs and will then not influence the composition of the Executive or the financial affairs of the Association.

  To download general information for 2014 about all programs and the subscription form 2014 click right mousebutton and save as...

 

EXPERIMENTAL TDM / ANTIVIRAL DRUGS PROGRAM:

The third round of 2014 we made a sample with the antiviral drugs: aciclovir, ganciclovir and ribavirine for the program Experimental TDM. The participants who indicated on their subscription form for 2014 to be interested in antiviral drugs receive a sample.

To download the form of test 2014.3 click right mousebutton and save as...

 

CLINICAL TOXICOLOGY PROGRAM:

The Clinical Toxicology program is based on real case histories. Drug spiked serum (lyophilised or liquid) or urine specimens (liquid) are distributed with the case history (see example of a toxicology test). The participants should perform analytical investigations and report the positive and/or negative results: identities and concentrations of the drug/poison found plus the methods of analysis used in addition. Interpretation of these lab data and the advices for medical treatment belongs to this program.

All individual results are collected in an anonymized overall report to all participants. Comments on selected assay methods and advices about treatment are added by the program coordinator professor dr.  D.R.A. Uges, or another hospital pharmacist-toxicologist.

The Toxicology Program started in 1977, in the Dutch language.  
On three occasions international studies were performed: Eurotox-studies 1983,1984 en 1990. 
Since 1994  we have also participants in the United Kingdom and Germany, 
so since that year the case history and the comments are also in the English language.

From 2000- 2003 we had twice a year a proficiency-test  with the UK-NEQAS. 

Survey of all tested components from 1977- up to the present, with links to the English case history and comment.

Example of a test case

Example of a test report 

For 2014 the costs for this program will be  285 (21% VAT not included)

 

DRUGS OF ABUSE  PROGRAM:  
In 1994 the KKGT started the program Drugs of Abuse. We sent 4x a year two urine samples.

For 2014 the costs will be  285 (21% VAT not included)

Survey of all tested components from 1994-up to the present with links to the reports

Example of a test case

Example of a test report 

To download the form of test 2014.3A click right mousebutton and save as...

To download the form of test 2014.3B click right mousebutton and save as...

 

ANTI-HIV  PROGRAM:

INTERNATIONAL INTERLABORATORY CONTROL PROGRAM 
FOR THERAPEUTIC DRUG MONITORING IN HIV INFECTION

The objectives of the program are to define sources of error in bioanalytical methods, to contribute to the optimisation of the bioanalysis of antiretroviral drugs and to establish interconvertibility of results among laboratories and methods. In the past years plasma samples have been sent, spiked with known amounts of antiretroviral drugs. The plasma has been obtained from HIV-negative healthy volunteers. Participating laboratories are asked to measure the concentration of the antiretroviral drugs and to report the results before the indicated date. Results will be interpreted and reported back to participants.

In  2014 we organize again two rounds. The costs will be: 400 (21% VAT not included)

To see the concentrations of 2013 click right mousebutton and save as...


 INTERNATIONAL QUALITY CONTROL PROGRAM FOR ANTIFUNGAL DRUGS

After a first free round of the International Interlaboratory Quality Control Program for Therapeutic Drug Monitoring of Antifungal drugs we now invite you to participate in the first and second round of this program. These rounds are organised by the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), in close collaboration with the Ph.D students R.J.M. Brüggemann (pharm D. UMCN ) and J.W. Alffenaar (pharm D. UMCG)  and dr. D.M. Burger  of the Radboud University Nijmegen Medical Centre and  prof. dr. D.R.A. Uges of the University Medical Center Groningen, the Netherlands .

The objectives of the program are to define sources of error in bioanalytical methods, to contribute to the optimisation of the bioanalysis of antifungal drugs and to establish interconvertibility of results among laboratories and methods and comparison of interpretations and dosage recommendations. 
Participating laboratories are asked to measure the concentration of the drugs and to report the results before the indicated date. Results will be interpreted and reported back to participants

In 2014 we organize again two rounds. The costs will be: 220 (21% VAT not included).

To see the concentrations of 2013 click right mousebutton and save as...

 

INTERNATIONAL QUALITY CONTROL PROGRAM FOR BIO-ANALYSIS OF TUBERCULOSIS DRUGS

in January 2012 a pilot study was started. This round was organised in close collaboration with dr. J.W.C. Alffenaar and prof dr. D.R.A. Uges of the University Medical Centre Groningen and dr. R.E. Aarnoutse of the Radboud University Nijmegen Medical Centre. The objective of this program was to define sources of error in bioanalytical methods, to contribute to optimisation of bioanalysis of anti-tuberculosis drugs and to establish interconvertibility of results among laboratories and methods.
This pilot round included two samples for the measurement of the following anti-tuberculosis drugs: ethambutol, isoniazid, linezolid, moxifloxacin, pyrazinamide, and rifampicin. The samples were prepared using the compounds in analytical quality, using human serum as matrix. The volume of each sample was 1 ml. Because of stability, samples were freeze-dried.
After delivery the samples must be stored at 4º - 8º C. After reconstitution the laboratory was asked to measure the concentration of the drugs as soon as possible because of stability after reconstitution is 12 hours at room temperature. Reconstituted samples can only be stored at – 80 º C.

To download the results of this pilot study click here

 

    For questions mail to info@kkt.nl  

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U kunt een e-mailbericht met vragen of opmerkingen over deze website verzenden aan info@kkgt.nl.