KKGT  Stichting Kwaliteitsbewaking Klinische Geneesmiddelanalyse en Toxicologie

Start

Nieuws

English Version

Bestuur

Programma's

Controle serum

Meest gestelde vragen

Concentraties testen

Uitslagformulieren

Verzendschema

Discussiedagen

Hyperlinks

 

WELCOME TO THE ASSOCIATION FOR QUALITY ASSESSMENT IN THERAPEUTIC DRUG MONITORING AND CLINICAL TOXICOLOGY

Welcome to the KKGT, which stand for  “Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology”.

The objective of the association is to stimulate the quality of  Therapeutic Drug Monitoring,  Clinical Toxicology and the analysis of other corporal-strange substances in laboratories. This includes determination of serumlevels, pharmacokinetic calculations and simulations, interpretation, together  resulting in a treatment advice to the physician.  

The Association has Articles, an Executive and an office. Participants to KKGT-EQAS will subscribe yearly to the programs and will then not influence the composition of the Executive or the financial affairs of the Association.

  To download general information for 2015 about all programs and order form for control serum 2015 click right mousebutton and save as...

When you want to participate you have to mail to office@skml.nl. Ordering control serum is only possible for participants.

 

CLINICAL TOXICOLOGY PROGRAM:

The Clinical Toxicology program is based on real case histories. Drug spiked serum (lyophilised or liquid) or urine specimens (liquid) are distributed with the case history (see example of a toxicology test). The participants should perform analytical investigations and report the positive and/or negative results: identities and concentrations of the drug/poison found plus the methods of analysis used in addition. Interpretation of these lab data and the advices for medical treatment belongs to this program.

All individual results are collected in an anonymized overall report to all participants. Comments on selected assay methods and advices about treatment are added by the program coordinator professor dr.  D.R.A. Uges, or another hospital pharmacist-toxicologist.

The Toxicology Program started in 1977, in the Dutch language.  
On three occasions international studies were performed: Eurotox-studies 1983,1984 en 1990. 
Since 1994  we have also participants in the United Kingdom and Germany, 
so since that year the case history and the comments are also in the English language.

From 2000- 2003 we had twice a year a proficiency-test  with the UK-NEQAS. 

Survey of all tested components from 1977- up to the present, with links to the English case history and comment.

Example of a test case

Example of a test report 

For 2015 the costs for this program will be  285 (21% VAT not included)

 

DRUGS OF ABUSE  PROGRAM:  
In 1994 the KKGT started the program Drugs of Abuse. We sent 4x a year two urine samples.

For 2015 the costs will be  300 (21% VAT not included)

Survey of all tested components from 1994-up to the present with links to the reports

Example of a test case

Example of a test report 

To download the form of test 2015.1A click right mousebutton and save as...

To download the form of test 2015.1B click right mousebutton and save as...

 

ANTI-HIV  PROGRAM:

INTERNATIONAL INTERLABORATORY CONTROL PROGRAM FOR THERAPEUTIC DRUG MONITORING IN HIV INFECTION

The objectives of the program are to define sources of error in bioanalytical methods, to contribute to the optimisation of the bioanalysis of antiretroviral drugs and to establish interconvertibility of results among laboratories and methods. In the past years serum samples have been sent, spiked with known amounts of antiretroviral drugs. The serum has been obtained from HIV-negative healthy volunteers. Participating laboratories are asked to measure the concentration of the antiretroviral drugs and to report the results before the indicated date. Results will be interpreted and reported back to participants.

These rounds are organised by the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), in close collaboration with prof. dr. D.M. Burger of the Radboud University Nijmegen Medical Centre.

 

 

Components

Antiretrovirals I

Antiretrovirals II

atazanavir

amprenavir

darunavir

efavirenz

lopinavir

etravirine

rilpivirine

nevirapine

ritonavir

raltegravir

saquinavir

tipranavir

 

 

 

 

In  2015 we organize four rounds. The costs will be: 400 (21% VAT not included)


 INTERNATIONAL QUALITY CONTROL PROGRAM FOR ANTIFUNGAL DRUGS

The objectives of the program are to define sources of error in bioanalytical methods, to contribute to the optimisation of the bioanalysis of antifungal drugs and to establish interconvertibility of results among laboratories and methods. In the past years serum samples have been sent, spiked with known amounts of antifungal drugs. The serum has been obtained from healthy volunteers. Participating laboratories are asked to measure the concentration of the antifungal drugs and to report the results before the indicated date. Results will be interpreted and reported back to participants.

These rounds are organised by the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), in close collaboration with dr. R.J.M. Brüggemann (UMCN ) and dr.J.W. Alffenaar (UMCG) 

 

Components

fluconazol

itraconazol

hydroxyitraconazol

voriconazol

posaconazol

flucytosine

 

In 2015 we organize four rounds. The costs will be: 250 (21% VAT not included).

 

INTERNATIONAL QUALITY CONTROL PROGRAM FOR BIO-ANALYSIS OF TUBERCULOSIS DRUGS

in January 2012 a pilot study was started. This round was organised in close collaboration with dr. J.W.C. Alffenaar and prof dr. D.R.A. Uges of the University Medical Centre Groningen and dr. R.E. Aarnoutse of the Radboud University Nijmegen Medical Centre. The objective of this program was to define sources of error in bioanalytical methods, to contribute to optimisation of bioanalysis of anti-tuberculosis drugs and to establish interconvertibility of results among laboratories and methods.
This pilot round included two samples for the measurement of the following anti-tuberculosis drugs: ethambutol, isoniazid, linezolid, moxifloxacin, pyrazinamide, and rifampicin. The samples were prepared using the compounds in analytical quality, using human serum as matrix. The volume of each sample was 1 ml. Because of stability, samples were freeze-dried.
After delivery the samples must be stored at 4º - 8º C. After reconstitution the laboratory was asked to measure the concentration of the drugs as soon as possible because of stability after reconstitution is 12 hours at room temperature. Reconstituted samples can only be stored at – 80 º C.

In 2015 we organize two rounds. The costs will be: 250 (21% VAT not included).   

 

ANTIVIRAL DRUGS PROGRAM:

The objectives of the program are to define sources of error in bioanalytical methods, to contribute to the optimisation of the bioanalysis of antiviral drugs and to establish interconvertibility of results among laboratories and methods. In the past year a freeze dried serum sample have been sent, spiked with known amounts of antiviral drugs.  The matrix is bovine serum. Participating laboratories are asked to measure the concentration of the drugs aciclovir, ganciclovir and ribavirine and to report the results before the indicated date. Results will be interpreted and reported back to participants.

These rounds are organised by the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology (KKGT), in close collaboration with dr. R. Aarnoutse

 

In 2015 we organize two rounds with two samples. The costs will be: 250 (21% VAT not included).   

For questions mail to info@kkt.nl  

terug naar boven

 

 

U kunt een e-mailbericht met vragen of opmerkingen over deze website verzenden aan info@kkgt.nl.